Glutathione

Glutathione (GSH) is described as the body’s most abundant intracellular antioxidant and a central component of cellular redox control. The protocol explains that GSH acts as a thiol-based buffer that neutralizes reactive oxygen species and supports Phase II detoxification pathways, including conjugation reactions that help the body eliminate xenobiotics and certain heavy metals. In the mechanism narrative, reduced glutathione donates electrons to quench oxidative species and is then recycled from its oxidized form (GSSG) by glutathione reductase, allowing continuous antioxidant turnover. The page frames adequate GSH status as supporting liver function, immune cell activity, mitochondrial protection, and overall cellular homeostasis. It also references research areas such as oxidative-stress marker reduction and potential skin-health effects (e.g., melanin index changes) in some studies. The protocol’s tolerability summary describes glutathione as generally well tolerated, with injection-site irritation as the most common issue and gastrointestinal discomfort mainly noted in higher-dose contexts.