single
HCG 5000IU
Standard Dosage Protocol
HCG 5000IU
Injection Freq.
Inject 3 times weekly
Cycle Sched.
8–12 weeks typical; extend to 16+ weeks for severe suppression cases
Reconstitution
2.0 mL BAC water
Helps maintain intratesticular testosterone and spermatogenesis during TRT (as described)
Helps prevent or reverse testicular atrophy associated with LH suppression
Supports endogenous testosterone recovery in hypogonadotropic contexts
Supports downstream hormone production (e.g., pregnenolone, DHEA) compared with exogenous testosterone alone (as described)
1
Reconstitution Requirements
- 2.0 mL BAC water
Escalation steps: 1
Defined through week 12
| Step | Week Range | Dose | Units |
|---|---|---|---|
| 1 | Weeks 1–12 | 500 IU | 20 |
Inject 3 times weekly
8–12 weeks typical; extend to 16+ weeks for severe suppression cases
HCG (human chorionic gonadotropin) is described as a glycoprotein hormone that is structurally similar to luteinizing hormone (LH) and activates the same LH receptors on testicular Leydig cells. The protocol explains that, by stimulating these receptors, HCG promotes endogenous testosterone production. A major mechanistic distinction highlighted is pharmacokinetics: while endogenous LH has a short half-life, HCG’s half-life is described as much longer (about 36 hours), producing more sustained gonadal stimulation per dose. The page frames this as useful in contexts where LH is suppressed, such as during exogenous testosterone exposure, to help maintain intratesticular testosterone and support spermatogenesis. It also describes higher-dose approaches used in fertility-restoration and post-suppression recovery scenarios. The protocol notes that because HCG increases testicular steroidogenesis, downstream estradiol can rise via aromatase, making estrogen-related monitoring a key safety consideration.
Estradiol elevation (may require monitoring/management)
Injection-site reactions (redness/swelling/discomfort)
Acne/oily skin
Testicular discomfort/sensitivity (often temporary)
Gynecomastia risk (rare
associated with elevated estradiol)
- Use aseptic technique: wipe vial stopper with alcohol; use new sterile syringe/needle
- Add diluent slowly down the vial wall to minimize foaming
- Gently swirl/roll until fully dissolved (do not shake)
- Label vial with reconstitution date and concentration; protect from light
- Refrigerate after reconstitution (commonly 2–8 °C) unless protocol states otherwise
- Avoid repeated freeze–thaw cycles
- Bacteriostatic Water for Injection contains benzyl alcohol preservative (multi-dose); follow protocol for beyond-use (many peptide protocols use ~28 days after mixing)
- Avoid benzyl-alcohol-containing diluents in neonates/infants (safety warning for benzyl alcohol)