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Melanotan II

10MG Protocol

Melanotan II 10MG

Injection Freq.

Inject once daily

Cycle Sched.

6–8 weeks for initial tanning, then switch to maintenance dosing

Reconstitution

3.0 mL BAC water

Increased skin pigmentation (tanning) without requiring UV exposure
Tanning effects often observed after several daily injections in early studies
Maintenance dosing may help sustain pigmentation after initial loading
Central melanocortin effects may influence arousal in some users
1

Reconstitution Requirements

  • 3.0 mL BAC water
StepWeek RangeDoseUnits
1Weeks 1–1250 mcg (0.25 mg)7.5
2Weeks 2–2500 mcg (0.5 mg)15
3Weeks 3–3750 mcg (0.75 mg)22.5
4Weeks 4–81000 mcg (1 mg)30
5Weeks 8–8500–1000 mcg (1–2× weekly)30

Inject once daily

6–8 weeks for initial tanning, then switch to maintenance dosing

Melanotan II is described as a synthetic cyclic analog of α-melanocyte-stimulating hormone that binds melanocortin receptors—particularly MC1R and MC4R. MC1R activation on melanocytes increases melanin production and distribution, which can raise skin pigmentation even without ultraviolet exposure. The protocol highlights that, with consistent subcutaneous administration during an initial “loading” phase, melanocortin receptor stimulation accumulates over time, leading to visible tanning effects after a short series of low daily doses in early human studies. Because melanocortin signaling also affects central pathways, the page notes that MC4R activation can influence sexual arousal in some individuals, which is sometimes reported as an effect during use. Overall, the mechanism emphasized is receptor-driven melanogenesis through MC1R, with additional MC4R-mediated central effects that can shape appetite and arousal-related responses.
Nausea (dose-dependent)
Facial flushing / increased skin warmth
Reduced appetite
Mild fatigue
Increased libido / spontaneous erections (men)
Injection-site reactions (redness/stinging)
  • Use aseptic technique: wipe vial stopper with alcohol; use new sterile syringe/needle
  • Add diluent slowly down the vial wall to minimize foaming
  • Gently swirl/roll until fully dissolved (do not shake)
  • Label vial with reconstitution date and concentration; protect from light
  • Refrigerate after reconstitution (commonly 2–8 °C) unless protocol states otherwise
  • Avoid repeated freeze–thaw cycles
  • Bacteriostatic Water for Injection contains benzyl alcohol preservative (multi-dose); follow protocol for beyond-use (many peptide protocols use ~28 days after mixing)
  • Avoid benzyl-alcohol-containing diluents in neonates/infants (safety warning for benzyl alcohol)