single10MG
Sermorelin
10MG Protocol
Sermorelin 10MG
Injection Freq.
Inject once daily
Cycle Sched.
3–6 months typical for adult research use; pediatric trials ran 6–12 months
Reconstitution
3.0 mL BAC water
Stimulates endogenous pulsatile GH release and physiologic IGF-1 elevation
Improved height velocity in pediatric GH deficiency in cited studies
Adult off-label research: possible support for body composition, energy, recovery, metabolic markers (limited evidence)
Preserves physiologic feedback vs exogenous GH, reducing overshoot risk
1
Reconstitution Requirements
- 3.0 mL BAC water
| Step | Week Range | Dose | Units |
|---|---|---|---|
| 1 | Weeks 1–2 | 200 µg (0.2 mg) | 6 |
| 2 | Weeks 3–4 | 300 µg (0.3 mg) | 9 |
| 3 | Weeks 5–6 | 400 µg (0.4 mg) | 12 |
| 4 | Weeks 7–8 | 500 µg (0.5 mg) | 15 |
Inject once daily
3–6 months typical for adult research use; pediatric trials ran 6–12 months
Sermorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) that binds GHRH receptors on pituitary somatotroph cells. Rather than supplying exogenous growth hormone, the protocol describes sermorelin as stimulating the body’s own pulsatile GH secretion. Because the signal is upstream, physiologic feedback loops remain intact: somatostatin and IGF-1 provide negative feedback that helps reduce the risk of excessive GH/IGF-1 exposure compared with direct GH administration. The resulting GH pulses drive hepatic and peripheral IGF-1 production and are linked in the protocol to anabolic processes such as protein synthesis, lipolysis, and tissue repair signaling. The page notes pediatric data showing improved height velocity in idiopathic GH deficiency with nightly dosing, while adult use is framed as extrapolated and dependent on an intact pituitary axis. In short, sermorelin works by restoring GHRH receptor signaling to promote physiologic GH pulses.
Injection-site reactions (pain/redness/swelling)
Headache (rare)
Flushing (rare)
Dizziness (rare)
Hyperactivity or drowsiness (rare)
Subclinical hypothyroidism reported in one study
- Use aseptic technique: wipe vial stopper with alcohol; use new sterile syringe/needle
- Add diluent slowly down the vial wall to minimize foaming
- Gently swirl/roll until fully dissolved (do not shake)
- Label vial with reconstitution date and concentration; protect from light
- Refrigerate after reconstitution (commonly 2–8 °C) unless protocol states otherwise
- Avoid repeated freeze–thaw cycles
- Bacteriostatic Water for Injection contains benzyl alcohol preservative (multi-dose); follow protocol for beyond-use (many peptide protocols use ~28 days after mixing)
- Avoid benzyl-alcohol-containing diluents in neonates/infants (safety warning for benzyl alcohol)