SLU-PP-332

SLU-PP-332 is described as a preclinical, small-molecule ‘exercise mimetic’ that works by activating estrogen-related receptors (ERRα/β/γ), with the strongest activity at ERRα. In the protocol’s ‘How This Works’ section, ERR activation is presented as switching on an aerobic-exercise transcriptional program that normally turns on with training. In mouse studies, this translated into higher mitochondrial respiration, increased fatty-acid oxidation in skeletal muscle, improved endurance capacity, and favorable cardiometabolic changes. Because the compound is positioned as mimicking training pathways without mechanical exercise stress, the protocol frames it as a tool for studying metabolic and mitochondrial biology rather than a conventional peptide hormone. Importantly, the page repeatedly emphasizes that evidence is limited to murine models (typically intraperitoneal dosing in studies) and that no human trials exist, so human pharmacokinetics, safety, and tolerability remain unknown.