single2MG
CJC-1295 DAC
2MG Protocol
CJC-1295 DAC 2MG
Injection Freq.
Inject once weekly
Cycle Sched.
8–12 weeks; optional 4-week break between cycles
Reconstitution
1.0 mL BAC water
Sustained elevation of GH and IGF-1 (clinical observations)
Potential support for lean body composition and recovery
Enhanced fat-metabolism signaling
Improved sleep quality (somnogenic effects described for GHRH analogs)
Preserves natural GH pulsatility
1
Reconstitution Requirements
- 1.0 mL BAC water
| Step | Week Range | Dose | Units |
|---|---|---|---|
| 1 | Weeks 1–12 | 2,000 mcg (2 mg) | 100 |
Inject once weekly
8–12 weeks; optional 4-week break between cycles
CJC-1295 DAC is a modified growth hormone–releasing hormone (GHRH) analog that incorporates a Drug Affinity Complex (DAC) designed to bind serum albumin after administration. The protocol explains that albumin binding markedly extends the compound’s functional half-life—from minutes to roughly a week—supporting once-weekly dosing. Biologically, CJC-1295 DAC binds GHRH receptors on pituitary somatotrophs, increasing growth hormone synthesis and amplifying pulsatile GH release. A key point emphasized is that, despite raising baseline GH levels, it is described as maintaining the natural rhythm of GH pulses rather than replacing physiologic secretion with continuous exogenous hormone exposure. Sustained downstream increases in IGF-1 are also highlighted, with clinical studies cited for multi-fold elevations that can persist for weeks during and after dosing cycles. Overall, the mechanism is extended-duration GHRH receptor activation that preserves pulsatility.
Transient flushing
Injection-site reactions
Water retention
Headache
- Use aseptic technique: wipe vial stopper with alcohol; use new sterile syringe/needle
- Add diluent slowly down the vial wall to minimize foaming
- Gently swirl/roll until fully dissolved (do not shake)
- Label vial with reconstitution date and concentration; protect from light
- Refrigerate after reconstitution (commonly 2–8 °C) unless protocol states otherwise
- Avoid repeated freeze–thaw cycles
- Bacteriostatic Water for Injection contains benzyl alcohol preservative (multi-dose); follow protocol for beyond-use (many peptide protocols use ~28 days after mixing)
- Avoid benzyl-alcohol-containing diluents in neonates/infants (safety warning for benzyl alcohol)