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single50MG

5-Amino-1MQ

50MG Protocol

5-Amino-1MQ 50MG

Injection Freq.

Inject once or twice daily

Cycle Sched.

Daily subcutaneous injections; each 50 mg vial provides 10–20 days of research material

Reconstitution

4.0 mL BAC water

May support reductions in fat mass while preserving lean mass (animal data)
Associated with higher NAD+ availability and SIRT1 pathway activation (preclinical)
Enhanced grip strength reported in aged mice when combined with exercise
1

Reconstitution Requirements

  • 4.0 mL BAC water
StepWeek RangeDoseUnits
1Weeks 1–22.5 mg once daily20
2Weeks 1+5 mg once daily40
3Weeks 1+2.5 mg twice daily20

Inject once or twice daily

Daily subcutaneous injections; each 50 mg vial provides 10–20 days of research material

5-Amino-1MQ is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes nicotinamide (vitamin B3) by methylating it using S-adenosylmethionine. In metabolic dysfunction, NNMT activity can be elevated in adipose tissue, which may reduce the pool of nicotinamide available for NAD+ biosynthesis. By limiting NNMT activity, 5-Amino-1MQ can help conserve nicotinamide for NAD+ production. Higher NAD+ availability is commonly linked with activation of sirtuin signaling (including SIRT1), pathways associated with mitochondrial biogenesis, cellular energy efficiency, and fat-oxidation signaling. In preclinical research, suppressing NNMT has been associated with improved metabolic markers and resistance to diet-driven weight gain without requiring reduced food intake.
Mild headache
Transient jitteriness
Injection-site reactions (redness/irritation)
  • Use aseptic technique: wipe vial stopper with alcohol; use new sterile syringe/needle
  • Add diluent slowly down the vial wall to minimize foaming
  • Gently swirl/roll until fully dissolved (do not shake)
  • Label vial with reconstitution date and concentration; protect from light
  • Refrigerate after reconstitution (commonly 2–8 °C) unless protocol states otherwise
  • Avoid repeated freeze–thaw cycles
  • Bacteriostatic Water for Injection contains benzyl alcohol preservative (multi-dose); follow protocol for beyond-use (many peptide protocols use ~28 days after mixing)
  • Avoid benzyl-alcohol-containing diluents in neonates/infants (safety warning for benzyl alcohol)

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